Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases
نویسندگان
چکیده
منابع مشابه
Estimating Per-Locus Mutation Rates
Relative per-locus mutation rates for Y-DNA microsatellites, and also for mitochondrial DNA singlenucleotide polymorphisms, can be estimated directly from diverse collections of haplotypes without segregating population components. The calibrated average mutation rates for the FTDNA panels of 12, 25, and 37 loci are 0.00187±0.00028, 0.00278±0.00042, and 0.00492±0.00074, respectively, from a col...
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Using the generalized stepwise mutation model, we propose a method of estimating the relative mutation rates of microsatellite loci, grouped by the repeat motif. Applying ANOVA to the distributions of the allele sizes at microsatellite loci from a set of populations, grouped by repeat motif types, we estimated the effect of population size differences and mutation rate differences among loci. T...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2002
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.10147